German Dog Study - Mobility DC Joint Health

STUDY DESIGN

  • Multicenter, non-randomized, uncontrolled study with one treatment group
  • Dogs with a lameness score of at least 2 (6 point scale 0-5) on day 0, no other medication or feed supplements for osteoarthritis or no prior surgery were enrolled in the study
  • Lameness was evaluated by the veterinary surgeon on days 0, 15 and 30
  • Dogs were administered a course of 30 days of treatment
  • Dog owners documented the treatment and completed a questionnaire on the effectiveness applicability and acceptance of Hyalutidin (Mobility DC) at the veterinary office on days 0, 15 and 30
  • 29 dogs completed the study (30 dogs enrolled, 1 failed to complete the study due to heart failure)

 RESULTS – VETERINARY SURGEON ASSESSMENT

Veterinary Surgeon Lameness Assessment

Below are the assessments on days 0, 15 and 30

SCORE (SCALE 0-5)

DAY 0

DAY 15

DAY 30

No Lameness (0)

0

0

0

Mild lameness walking   (1)

0

2

11

Mild lameness trotting   (2)

12

17

10

Moderate lameness        (3)

10

8

6

Severe lameness              (4)

5

2

2

Very severe lameness     (5)

2

0

0

Total

29

29

29

  

Veterinary Surgeon Analysis of Improvement

Improvement by scores on day 15 and day 30

SCORE

DAY 15

Day 30

Improvement by 2 points

1

6

Improvement by 1 point

14

15

Unchanged

14

8

  • By day 15 the number of dogs with mild lameness (score 1-2) had increased from 41.4% (12) to 65.5% (19)
  • By day 15 the number of dogs with severe lameness (score 4-5) had decreased from 24.1% (7) to 6.9% (2)
  • The two dogs with very severe lameness (score - 5) had improved by one and two scores respectively
  • By day 15 greater than 50% (15) dogs had improved at least one score
  • No animal deteriorated during the study period
  • By day 30 the number of dogs with mild lameness (score 1-2) had increased from 41.4% (12) at day 0 to 72.4% (21)
  • By day 30 72.4% (21) had improved and 8 remained unchanged
  • The reported improvement is statistically significant (p < 0.0001)

 RESULTS – DOG OWNERS ASSESSMENT

  • The dog owners assessed the efficacy of the treatment by answering 7 questions related to the dogs behaviour
  1. Jumping into the car
  2. Climbing stairs
  3. Stiffness after long periods of rest
  4. Sensitivity in the legs and hips
  5. Limping
  6. Expression of pain
  7. Unwillingness to run and play

Owners Lameness Assessment

  • Each parameter was evaluated on a scale of 1-9 (1 best 9 worst)
  • Results of all categories were summed with the following results

The improvement after both Days 15 and 30 were statistically significant (p < 0.0001)

 

DAY 0

DAY 15

DAY 30

Mean

29.8

25.5

22.6

Median

27

23

21


Owners Analysis of Improvement

  • Dog owners confirmed the lameness assessments by the veterinary surgeons, their evaluation on a scale of 1-9 resulted in the following improvements:

DAY 0 Average

DAY 15 Average

DAY 30 Average

5.21

4.31

3.83

 

  • 93.1% of owners assessed improvement in the dogs condition after 30 days, results of assessments of improvements, compared to day 0 on a scale of 1-9, after both 15 and 30 days are as follows:

 

SCORE

DAY 15

DAY 30

Clear Improvement (1-2)

2

9

Improvement           (3-4)

20

18

No Change                (5)

6

2

Decline                      (6-7)

1

0

Clear Decline            (8-9)

0

0


CONCLUSIONS:

  • Even in a small sample size the study demonstrates that a 30 day course of treatment with Hyalutidin (Mobility DC) achieves a significant improvement in clinical lameness from various types of osteoarthritis
  • The lameness as assessed by the veterinary surgeons improved in 72.4% of the dogs over the study period
  • An assessment of the dogs condition by the dog owners  showed an improvement in 93.1% of the dogs
  • Clear improvement was seen in dogs with severe lameness
  • No side effects were reported
  • Palatability of the product was rated very good
  • A small number of dog owners complained of difficulty reading the measuring cup and the sticky consistency of the product